Clinical Background

Glaucoma is currently the leading reason of irreversible blindness in the world. It is commonly caused by elevated intraocular pressure (IOP), which causes mechanical straining and torsion of optic nerve and loss of retinal nerve fibers. Glaucoma changes the morphology of optic nerve head (ONH) and is usually characterized by the larger cup to disc ratio (CDR), pale disc, disc hemorrhage, etc. in the ONH region, while in OCT images thinning of retinal nerve fiber layer could be seen at the early stage.

 

The optic cup is the central cup-like area in the optic disc. The CDR is the comparison of the diameter of the cup to disc, which partially represents disease status. Determination of CDR varies among doctors and can be influenced by subjectivity. The normal CDR is 0.3 to 0.4. A larger CDR may indicate glaucoma or other diseases such as neuro-ophthalmic diseases. Previous studies showed that larger vertical (not horizontal) CDR is closely associated with progression of glaucoma. Although not accurate enough, CDR is very useful in clinical practice and evaluation of glaucoma.

 

Fundus Camera Manufacturers

The images available in this Challenge are acquired with two different fundus cameras:

Zeiss Visucam 500 (2124x2056 pixels) - For Training

Canon CR-2 (1634x1634 pixels) - For Validation and Test

 

All images are centered at the posterior pole with both macula and optic disc.

 

With this challenge, we set up a large dataset of fundus photos from both non-glaucoma subjects (90%) and glaucoma patients (10%).